Personalized medicine
Personalized medicine research area combines large-scale state-of-art technologies and computational approaches to investigate health and gastrointestinal diseases at the single-cell or molecular level (epigenetic, genetic, etc.). It is comprised of multidisciplinary team of molecular biologists, gastroenterologists, and computational biologists, linking clinical research with basic science.
Research interests
– Integration of computational approaches for the diagnostics and monitoring of gastrointestinal diseases, in line with the principles of precision medicine.
– Clinical and epidemiological studies, improvement of health policies and screening programs for gastrointestinal diseases.
– Identification of novel non-invasive diagnostic targets through the integration of molecular multi-omics data (e.g., cell-free DNA, targeted proteomics, miRNA, gene expression).
– Investigation of gastrointestinal diseases at the single-cell level to uncover cellular mechanisms and heterogeneity.
– Molecular and clinical research on rare gastrointestinal and liver-related diseases, including Wilson’s disease, hemochromatosis, and Budd-Chiari syndrome.
Core facilities
– Gastrointestinal and liver disease biobank.
– Molecular analysis (genotyping, qPCR, etc.).
– Targeted proteome analysis (ELISA, Western Blot).
– NGS facilities (QC, WES, transcriptome, miRNome, targeted sequencing).
– Single-cell analysis (cell dissociation, MACS, FACS, 10x Genomics Chromium).
– Computational resources.
Main contacts
