Klebsiella pneumonia

Klebsiella pneumoniae (K. pneumoniae) is a highly prevalent and antibiotic-resistant bacterium, known for causing both community-acquired and hospital-associated infections, especially in immunocompromised patients. It can colonize various parts of the body, including the skin, pharynx, and gastrointestinal tract, leading to a variety of diseases such as bacteremia, pneumonia, urinary tract infections, bloodstream infections, and liver abscesses. 

Gram-negative bacteria, including Klebsiella pneumoniae, can produce narrow-spectrum antimicrobial proteins called bacteriocins (referred to as klebicins when produced by K. pneumoniae). Bacteriocins have emerged as a promising alternative to conventional antibiotics. Unlike broad-spectrum antibiotics, bacteriocins are highly specialized proteins that can recognize and eliminate species-specific pathogens without disrupting the delicate balance of the host microbiota.