Translational research
The Institute for Digestive Research performs fundamental and translational research, utilizing functional studies to uncover the mechanisms behind gastrointestinal disorders, with a focus on inflammatory diseases and cancer.
Our main activities range from the experimental validation of epigenetic and genetic targets, screening of therapeutic and other exogenous substances, to the development of complex in vitro and in vivo GI disease models to study host-microbiome interactions, metabolome, and mechanisms of a variety of GI pathologies, including inflammatory bowel diseases, microscopic colitis, colorectal and gastric cancers, etc.
Research interests
– Gastrointestinal Oncology and Cancer Biology.
– Screening of Therapeutics, Drugs, and Exogenous Substances, including newest research on Metabolites.
– Microbiome-Host Interactions in Gastrointestinal Diseases.
– Development of In Vitro Models for Gastrointestinal Diseases, including 3D Organoids and Co-Cultures.
– Development of In Vivo Models for Gastrointestinal Diseases, with focus on Murine Models.
Core facilities
– Cell culture.
– In vitro organoid models.
– Murine models.
– Flow cytometry.
– Microscopy.
– Protein analysis.
Main contacts
